THE CYCLIC BRAIN: A SYSTEMIC REVIEW OF PREMENSTRUAL DYSPHORIC DISORDER

Authors

  • Lizzete Jazmín Lovera Mendoza Universidad Nacional Autónoma de México
  • Gabriela Orozco Calderón Universidad Nacional Autónoma de México

Keywords:

premenstrual syndrome, menstrual cycle, cognition, neuroendocrine, hormonal fluctuations

Abstract

About 3-8% of all women of reproductive age suffer from premenstrual dysphoric disorder (PMDD), which prevents them from living a normal life during the luteal phase (premenstrual phase) of the menstrual cycle. Throughout the premenstrual phase, women may experience emotional, cognitive and physiological changes. However, premenstrual dysphoric disorder represents one of the most severe versions of premenstrual syndrome (PMS), referring to the intensity of emotional and physical symptoms that occur during the luteal phase. More research and understanding is necessary in order to find the right treatment. This work is aimed to provide a review of the most significant research around this topic, highlighting the brain and cognitive implications that many women report during the last phase of the menstrual cycle, specifically in processes such as working memory, anticipation, decision making and inhibitory control that so far are the most reported in literature. 

References

American College of Obstetricians and Gynecologists. (2001). ACOG practice bulletin: premenstrual syndrome. Int J Gynaecol Obstet, 73, 183-191.

American Psychological Association [APA]. (2014). Manual de diagnóstico y estadístico de los trastornos mentales (DSM-5). Editorial Médica Panamericana.

Aperribai, L., Alonso-Arbiol, I., Balluerka, N., & Claes, L. (2016). Development of a screening instrument to assess premenstrual dysphoric disorder as conceptualized in DSM-5. Journal of Psychosomatic Research, 88, 15-20. https://www.sciencedirect.com/science/article/pii/S0022399916303373

Bäckström, T., Bixo, M., Johansson, M., Nyberg, S., Ossewaarde, L., Ragagnin, G., ... & Van Wingen, G. (2014). Allopregnanolone and mood disorders. Progress in neurobiology, 113, 88-94. https://www.sciencedirect.com/science/article/pii/S0301008213000671

Bannbers, E., Kask, K., Wikström, J., Risbrough, V., & Sundström Poromaa, I. (2011). Patients with premenstrual dysphoric disorder have increased startle modulation during anticipation in the late luteal phase period in comparison to control subjects. Psychoneuroendocrinology, 36(8), 1184-1192. https://www.sciencedirect.com/science/article/pii/S0306453011000825

Catenaccio, E., Mu, W. & Lipton, M. L. (2016). Estrogen-and progesterone-mediated structural neuroplasticity in women: evidence from neuroimaging. Brain Structure and Function, 221(8), 3845-3867

Comasco, E., Hahn, A., Ganger, S., Gingnell, M., Bannbers, E., Oreland, L., ... & Sundström‐Poromaa, I. (2014). Emotional fronto‐cingulate cortex activation and brain derived neurotrophic factor polymorphism in premenstrual dysphoric disorder. Human brain mapping, 35(9), 4450-4458. https://onlinelibrary.wiley.com/doi/abs/10.1002/hbm.22486

Davey, C.G., Whittle, S., Harrison, B.J., Simmons, J.G., Byrne, M.L., Schwartz, O.S. & Allen, N.B. (2015). Functional brain-imaging correlates of negative affectivity and the onset of first-episode depression. Psychol Med, 45 (2015) 1001-1009. https://www.cambridge.org/core/journals/psychological-medicine/article/functional-brainimaging-correlates-of-negative-affectivity-and-the-onset-of-firstepisode-depression/52016E21676A739D923BFFA4F347A8E0

de Pediatría, S. A., & Subcomisiones, C. (2010). Trastornos del ciclo menstrual en la adolescencia. Arch Argent Pediatr, 108(4), 363-369. https://www.scielo.org.ar/scielo.php?pid=S0325-00752010000400018&script=sci_arttext

Dorador-González, M.D. & Orozco-Calderón, G. (2021). Evaluación neuropsicológica breve en las diferentes etapas del climaterio. Ciencia & Futuro, 11(1). 135-153. https://revista.ismm.edu.cu/index.php/revistacyf/article/view/2039

Dreher, J. C., Schmidt, P. J., Kohn, P., Furman, D., Rubinow, D. & Berman, K. F. (2007). Menstrual cycle phase modulates reward-related neural function in women. Proceedings of the National Academy of Sciences, 104(7), 2465-2470. https://www.pnas.org/doi/abs/10.1073/pnas.0605569104

Dubol, M., Epperson, N., Lanzenberger, R., Sundström-Poromaa, I. & Comasco, E. (2020). Neuroimaging premenstrual dysphoric disorder: A systematic and critical review, Frontiers in Neuroendocrinology, doi: https://doi.org/10.1016/j.yfrne.2020.10083

Epstein, J., Pan, H., Kocsis, J. H., Yang, Y., Butler, T., Chusid, J., ... & Silbersweig, D. A. (2006). Lack of ventral striatal response to positive stimuli in depressed versus normal subjects. American Journal of Psychiatry, 163(10), 1784-1790

Etkin, A. & Schatzberg, A.F. (2011). Common abnormalities and disorder-specific compensation during implicit regulation of emotional processing in generalized anxiety and major depressive disorders. Am J Psychiatry, 168, 968-978. https://psychiatryonline.org/doi/full/10.1176/appi.ajp.2011.10091290

Farage, M. A., Osborn, T. W., & MacLean, A. B. (2008). Cognitive, sensory, and emotional changes associated with the menstrual cycle: A review. Archives of Gynecology and Obstetrics, 278(4), 299–307.

Gingnell, M., Bannbers, E., Wikström, J., Fredrikson, M., & Sundström-Poromaa, I. (2013). Premenstrual dysphoric disorder and prefrontal reactivity during anticipation of emotional stimuli. European Neuropsychopharmacology, 23(11), 1474–1483 https://www.sciencedirect.com/science/article/pii/S0924977X13002150

International Classification of Diseases. (2017). International Statistical Classification of Diseases and Related Health Problems. Recuperado de: PREMENSTRUAL DYSPHORIC DISORDER 45 http://apps.who.int/classifications/icd11/browse/l-m/en#/

Kiesner, J., & Granger, D. A. (2016). A lack of consistent evidence for cortisol dysregulation in premenstrual syndrome / premenstrual dysphoric disorder. Psychoneuroendocrinology,65, 149–164.

Ko, C. H., Long, C. Y., Yen, C. F., Chen, C. S., Wang, P. W., & Yen, J. Y. (2014). Gonadotrophic hormone and reinforcement sensitivity systems in women with premenstrual dysphoric disorder. Psychiatry and Clinical Neurosciences, 68(11), 785-794. https://onlinelibrary.wiley.com/doi/abs/10.1111/pcn.12189

Lin, P. C., Ko, C. H., & Yen, J. Y. (2022). Early and late luteal executive function, cognitive and somatic symptoms, and emotional regulation of women with premenstrual dysphoric disorder. Journal of Personalized Medicine, 12(5), 819. https://www.mdpi.com/2075-4426/12/5/819

Martini, F. H., Nath, J. L., & Bartholomew, E. F. (2012). Fundamentals of Anatomy and Physiology (9th Edition). Pearson Education, Inc.

Pessoa, L. (2017). Network Model of the Emotional Brain. Trends Cogn Sci, 21, 357-371. https://www.cell.com/trends/cognitive-sciences/abstract/S1364-6613(17)30036-0

Petersen, N., Ghahremani, D. G., Rapkin, A. J., Berman, S. M., Liang, L., & London, E. D. (2018). Brain activation during emotion regulation in women with premenstrual dysphoric disorder. Psychological medicine, 48(11), 1795-1802. https://www.cambridge.org/core/journals/psychological-medicine/article/brain-activation-during-emotion-regulation-in-women-with-premenstrual-dysphoric-disorder/204CF070BBE151ABD97FE2CDE3CFB384

Protopopescu, X., Tuescher, O., Pan, H., Epstein, J., Root, J., Chang, L., Altemus, M., Polanecsky, M., McEwen, B., Stern, E. & Silbersweig, D. (2008). Toward a functional neuroanatomy of premenstrual dysphoric disorder. J Affect Disord 108, 87-94.

Rapkin, A. J., Berman, S. M., Mandelkern, M. A., Silverman, D. H., Morgan, M., & London, E. D. (2011). Neuroimaging evidence of cerebellar involvement in premenstrual dysphoric disorder. Biological psychiatry, 69(4), 374-380. https://www.sciencedirect.com/science/article/pii/S0006322310009984

Reed, S. C., Levin, F. R., & Evans, S. M. (2008). Changes in mood, cognitive performance and appetite in the late luteal and follicular phases of the menstrual cycle in women with and without PMDD (premenstrual dysphoric disorder). Hormones and behavior, 54(1), 185-193. https://www.sciencedirect.com/science/article/pii/S0018506X08000603

Schmahmann, J. D., Oblak, A. L., & Blatt, G. J. (2021). Cerebellar connections with limbic circuits: anatomy and functional implications. In Handbook of the Cerebellum and Cerebellar Disorders (pp. 605-624). Cham: Springer International Publishing. https://link.springer.com/content/pdf/10.1007/978-3-030-23810-0_22.pdf

Shakiba, A. (2014). The role of the cerebellum in neurobiology of psychiatric disorders. Neurologic clinics, 32(4), 1105-1115. https://www.neurologic.theclinics.com/article/S0733-8619(14)00062-0/abstract

Slyepchenkoa, A., Lokugea, S., Nichollsa, B., Steinera, M., Hall. G., Soares, C.N. & Frey, B.N. (2017). Subtle persistent working memory and selective attention deficits in women with premenstrual syndrome. Psychiatry Research. 249, 354–362. https://www.sciencedirect.com/science/article/pii/S0165178116310058

Tremblay, L.K., Naranjo, C.A., Graham, S.J., Herrmann, N., Mayberg, H.S., Hevenor, S. & Busto, U.E. (2005). Functional neuroanatomical substrates of altered reward processing in major depressive disorder revealed by a dopaminergic probe. Arch Gen Psychiatry, 62, 1228-1236.

Wiklund, L. (2017). Premenstrual Dysphoric Disorder - A Review of Neural and Cognitive Changes in Women with PMDD. [tesis de licenciatura]. University of Skovde.

Yen, J. Y., Chang, S. J., Ko, C. H., Yen, C. F., Chen, C. S., Yeh, Y. C., & Chen, C. C. (2010). The high-sweet-fat food craving among women with premenstrual dysphoric disorder: emotional response, implicit attitude and rewards sensitivity. Psychoneuroendocrinology, 35(8), 1203-1212. https://www.sciencedirect.com/science/article/pii/S030645301000051X

Yen, J. Y., Chang, S. J., Long, C. Y., Tang, T. C., Chen, C. C., & Yen, C. F. (2012). Working memory deficit in premenstrual dysphoric disorder and its associations with difficulty in concentrating and irritability. Comprehensive psychiatry, 53(5), 540-545. https://www.sciencedirect.com/science/article/pii/S0010440X11001349

Published

2025-06-15

How to Cite

Lovera Mendoza, L. J., & Orozco Calderón, G. (2025). THE CYCLIC BRAIN: A SYSTEMIC REVIEW OF PREMENSTRUAL DYSPHORIC DISORDER. Revista De Innovación Social Y Desarrollo, 10(1), 1–20. Retrieved from https://revista.ismm.edu.cu/index.php/indes/article/view/2762

Issue

Section

Con mirada crítica